Publications and Presentations

Our therapeutic targets are chosen based on years of cutting-edge bioenergetics and mitochondrial function research by Pretzel's founders, and our lead programs are built on a strong foundation of biochemical and pharmacological data

Small molecules restore mutant mitochondrial DNA polymerase activity

Valenzuela, S., Zhu, X., Macao, B. et al. Small molecules restore mutant mitochondrial DNA polymerase activity. Nature (2025). doi.org/10.1038/s41586-025-08856-9

Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity

Jiang, S., Yuan, T., Rosenberger, F.A. et al. Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nat Metab 6, 1024–1035 (2024). doi:10.1038/s42255-024-01038-3

Mitochondrial DNA copy number in human disease: the more the better?

Filograna R, Mennuni M, Alsina D, Larsson NG. Mitochondrial DNA copy number in human disease: the more the better?. FEBS Lett. 2021;595(8):976-1002. doi:10.1002/1873-3468.14021

Maintenance and Expression of Mammalian Mitochondrial DNA

Gustafsson CM, Falkenberg M, Larsson NG. Maintenance and Expression of Mammalian Mitochondrial DNA. Annu Rev Biochem. 2016;85:133-160. doi:10.1146/annurev-biochem-060815-014402